Identification of a new class of HIV-latency reversing agents

Andrea Gramatica is a postdoctoral scholar in Warner Greene’s laboratory at the Gladstone Institute of Virology and Immunology. Andrea received his PhD in Cell Biology in Germany, from the Humboldt University Berlin, where he studied the role of key cellular pathways during HIV assembly and release, and developed an innovative nanomedical system for clearance of HIV-particles by macrophages. His current research focuses on the study of HIV-1 latency reversion, ex vivo, in CD4 T cells from HIV-infected individuals on ART. Specifically, his research is dedicated to the identification and analysis of novel and non-toxic latency reversing agents that are non-toxic, prevent broad T cell activation, but are able to induce LTR transcription and virus pro­duction.