CFAR 2005 Symposium: Emerging Concepts in Antiretroviral Therapy

This two-day symposium examined antiretroviral therapy (ART) from the research clinician's perspective, including novel applications of ART in patient settings, new data on early infection and transmission of resistance, and chemokine receptor biology in the context of patient therapy. The symposium also sought to foster and facilititate novel, multidisciplinary research collaborations between basic science investigators and clinicians.

Presentations

Welcome: Paul A. Volberding, MD and Diane Havlir, MD

Day 1 Morning Session: The Research Frontier of Antiretroviral Therapy

Session Moderators: Drs. Harry Lampiris and Laura Napolitano

  • HIV Adaptation: Genetic Hurdle, Selective Advantage and Replicative Cost
    Simon Mallal, MD, Professor and Executive Director Center for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital
  • The Central Challenges of Viral Eradication
    Joseph K. Wong, MD, Assistant Adjunct Professor of Medicine, UCSD/VAMC
  • Immune Activation, Viral Fitness and Disease Progression
    Steven G. Deeks, MD, Associate Clinical Professor of Medicine, UCSF
  • Combating Susceptibility to Drug Resistance: Lessons from HIV-1 Pprotease
    Celia Schiffer, PhD, Professor, Biochemistry and Molecular Pharmacology, University of Massachusetts
    Medical School
  • Moderated Panel Discussion

Day 1 Afternoon Session: Chemokine Receptors and Implications for Therapy

Session Moderators: Drs. Ruth Greenblatt and Warner C. Greene

  • Epidemiology and Pathogenesis of HIV-1 Co-receptor Tropism
    Eric Daar, MD, Professor of Medicine, David Geffen School of Medicine, UCLA
  • Development of Chemokine Receptor Inhibitors and Potential Callenges in Application
    Howard Mayer, MD, Senior Researcher, Global Research and Development, Pfizer, Inc.
  • Assays for HIV-1 Co-receptor Utilization and Inhibitor Resistance: Potential Clinical Applications
    Chris Petropoulos, PhD, Vice President, Virologic, Inc.
  • Moderated Panel Discussion

Day 2 Morning Session: Biology of Early Infection and Transmission of Resistance

Session Moderators: Drs. Jay Levy and Rick Hecht

  • Evolution of Transmitted Resistance
    Walid Heneine, PhD, Chief of the Molecular Epidemiology and Zoonoses Section, HIV and Retroviral Branch - Centers for Disease Control and Prevention
  • HIV-1 Genetic Variation and Drug Resistance: Implications for Developing Countries
    Robert Shafer, MD, Assistant Professor of Medicine, Stanford University
  • Recombination and Superinfection
    Lisa Demeter, MD, Associate Professor, University of Rochester Medical Center
  • Epidemiology of Transmitted Resistance
    Robert M. Grant, MD, MPH, Senior Investigator, Gladstone Institute of Virology and Immunology
  • How Does HIV Infection Cause Immune Deficiency?
    Michael Lederman, MD, Professor of Medicine, Case Western Reserve University
  • Moderated Panel Discussion